Prophylactic effect of citalopram in unipolar, recurrent depression

Prophylactic citalopram reduced recurrences of unipolar major depression.

P a t i e n t s 121 outpatients ≥ 65 years of age (mean age 75 y, 77% women) with unipolar major depression (Diagnostic and Statistical Manual of Mental Disorders, 4th edition [DSM-IV], 296.2x or 296.3x and Montgomery Åsberg Depression Rating Scale [MADRS] score ≥ 22) who responded to acute and continuation treatment with citalopram (20 to 40 mg) for 8 and 16 weeks, respectively. Response to bo...

Recurrent unipolar depression requires prolonged treatment.

Psychiatric disorder is now recognised as Psychiatric disorder is now recognised as one of the greatest causes of human one of the greatest causes of human suffering. The burden to society of various suffering. The burden to society of various diseases has been quantified recently using diseases has been quantified recently using disability-adjusted life years (DALYs), a disability-adjusted lif...

A study of recurrent unipolar major depression and executive functions

Unipolar Depression in Paroxysmal Schizophrenia

Based on the current study, the clinical characteristics of unipolar depression in the clinical picture of schizophrenia with the paroxysmal type of disease course are presented. Given the concomitant depression with phobic symptoms, the following clinical variants are marked: depression with generalized social phobia and/or anthropophobia and depression with generalized pathological body sensa...

Bipolar and unipolar depression.

Since Kraepelin grouped affective disorders under the title of 'manic-depressive insanity', there has been controversy over whether the bipolar and unipolar entities within this are distinct affective disorders or whether they are merely two ends of an affective continuum. In order to bring some clarity and goal-posts to this argument, we define the criteria that must be fulfilled by diseases i...